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Universidad Autónoma de Madrid. Facultad de Medicina. Departamento de Farmacología and Hospital Univ
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Type of institution
Composed by researchers from both institutions with a wide experience in joint grants and papers in the topic of endothelial dysfunction. Our work has been foccussed in two main areas where vascular damage is very relevant and the role for endothelium is crucial, such as elderly and diabetes mellitus. Our studies include in vivo studies in animal models and humans, as well as cell culture and isolated vessels or tissues from healthy young and aged human subjects or diabetic parients. The experimental approaches are covering since cell and molecular biology techniques to in vitro vascular reactivity or in vivo non-invasive vascular studies. We can also participate in epidemiological cohort studies. During the last years, we have also investigated other topics related to elderly and diabetes. Thus, we aim to analyze the role of frailty as a factor triggering the development of disability risk and other health adverse effects (falls, hospital stays, geriatric residence internships, or deaths). We are also studying the influence of visceral fat as a source of inflammatory agents that can generate vascular damage in two situations in which visceral fat is increased, like obesity and aging
1.- Mechanisms of vascular damage in diabetes: interaction between inflammation and hyperglycaemia
2.- Mechanisms of human vascular aging
3.-Obesity, insulin resistance, adippokines, and vascular dysfunction.
4.- The role of angiotensin (1-7)/Mas receptor axis in vascular function and inflammation
Main research areas
Diabetic vasculopathy, obesity and vascular dysfunction, vascular aging.
Carlos F. Sánchez Ferrer (Leader researcher)
Laboratory L-5 in the Departamento de Farmacología
Calle Arzobispo Morcillo, 4