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Department Of Neurology, Clinical Research Center, University Of Kuopio
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Type of institution
Five research groups are working in the Department of Neurology, UKU and Clinical Research Center, Mediteknia that are conveniently located near the Department of Neurology in Kuopio University Hospital. The staff includes 42 persons working in Alzheimer and memory disorder research: 2 professors, 3 research directors, 4 senior investigators, 10 postdocs, 15 PhD students and 11 technicians. The Alzheimer research group is a member of Nordic Centre of Excellence in "Molecular mechanisms of neurodegenerative diseases". Kuopio Brain Bank is a member of the Brain Net Europe, a consortium of excellence supported by EU.
We have long-term experience in clinical research on Alzhimer's disease (AD) and other memory disorders aiming at improvement in clinical diagnostics, therapy and prevention. We also focus on health economic aspects of dementia and memory disorders. Our goal is to understand the interactions between genetic and life style risk factors in the pathogenesis of neurodegenerative diseases, especially Alzheimer's disease (AD). Three main approaches are used. (1) The human approach assesses well-characterized populations regarding clinical phenotype, genetic and life style risk factors, blood and CSF biomarkers, imaging and neuropathology. (2) Hypotheses arising from human studies are tested in well-controlled experimental animal models employing modern gene manipulation techniques. (3) The cell-culture approach analyzes molecular details of the underlying mechanisms of interaction. We also run a longitudinal study on health economics and quality of life of rehabilitation and counseling of AD patients and their caregivers.
Main research areas
The major projects are focusing on epidemiology and risk factors, genetics in population-based, clinical and neuropahologically verified cohorts, neuroimaging, and biomarkers of neurodegeneration. Our focus is on elderly populations and in particular cognitive functions and dysfunction and strategies to prevent cognitive decline and to improve cognitive impairment.
Basic natural sciences,Medical/Clinical Sciences/Nursing
Hilkka Soininen, MD, PhD, Professor in neurology
Department of Neurology
University of Kuopio