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Funder/CentreGerman Research Foundation (Deutsche Forschungsgesel...
Programme:Cellular mechanisms of Alzheimers's disease (SPP 10...
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Cellular mechanisms of Alzheimers's disease (SPP 1085)Research Programme


Programme type

Research programme

Programme status


Total number of funded projects


Summary of key aims

Alzheimer's disease (AD) is characterized by the invariable accumulation of senile plaques, neurofbrillary tangles, and inflammatory processes. These pathological events are involved in the fatal neuronal cell observed in the brains of the patients. At lease five gene products (B-amyloid precursor protien, tau, Presenilin-1, Presenilin-2 and apoE) play a pivotal role in the pathogenesis of AD. It appears that miss-sorting and/or miss-function of these proteins is directly involved in amyloid plaque formation as weel as the accumulation of neurofibrillary tangles. Therefore a detailed understanding of the cell biology of these proteins and their cellular function will pave the way to understanding the patthological mechanisms causing AD. This may also help to identify novel targets for theraputic treatment. This program is therefore aimed to combine the efforts in cell biology and AD research and to provide a network within these two disciplines.

Management contact

Astrid Golla
Kennedyallee 40
53175 Bonn

Scientific contact

Christian Haass
Ludwig-Maximilians-Universitat Munchen
Schillerstrasse 42/44
80336 Muchen

Funding contact

Deutsche Forschungsgemeinschaft
Kennedyallee 40
53175 Bonn

Is the project externally evaluated?


Who has evaluated, or will evaluate, the programme?


What forms of international collaboration does the programme support?

  • ▪ Foreign collaborators working in their own countries
  • ▪ Travel for foreign collaborators
  • ▪ National researchers abroad
  • ▪ Travel for national researchers

Interdisciplinary research is a strategic priority...

  • For the programme ✔
  • For the funding agency ✔
  • Nationally ✔