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Funder/CentreGerman Research Foundation (Deutsche Forschungsgesel...
Programme:Molecular Targets of the Ageing Process and Strategi...
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German Research Foundation (Deutsche Forschungsgesellschaft)

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Molecular Targets of the Ageing Process and Strategies for the Prevention of Ageing (Research Training Group 1033)Research Programme


Programme type

Research programme

Programme status


Total number of funded projects


Summary of key aims

The research programme of the Research Training Group foucuses on the role of oxidative stress in ageing and the corresponding theraputic prevention strategies. To our knowledge the following basic mechanistic principles have to be considered in this context: The balance between generation and detoxification/repair of damaged macromolecules, a mechanisim which (a) contributes to the accumulation of pathologic progeric protein aggregates and the associated degenerative processes and (b) could be limiting for the function of the genome and the mitochondria; furthermore (c), the senescent or dies. Regarding to these three major types of ageing mechanisms we offer ten thesis projects in this Research Training Group. The indiviual projects are interconnected by the underlying research area "oxidative stress and ageing processes" as well as by common topics (accumulation/degradation of damaged proteins; integritity of the mitochondrial genome; opoptosis and senescence; antioxidants/osmolytes and prevention). Each topic is explored by at least two research groups from different perspectives. This homogenous and interconnected framework is represented by the structure of the training programme. Consequently the realisation of each thesis project requires experimental work in the primary laboratory (thesis supervisor) and at least two complementary laboratories (tutors). Research and study programme thus cover the whole spectrum from basic research to clinical medicine. The high relevance of this research area for training of medical and biology students results from the demographic development which predicts an increase of aged people in the population and ageing-associated diseases.

Management contact

Carolyn Heyder
+49- [0]2 28-8 85 27
Kennedyallee 40
53175 Bonn

Scientific contact

Jean Krutman
(0211) 3389-224
Heinrich-Heine-Universitat Dusseldorf
Auf'm Hennekamp 50
40225 Dusseldorf

Funding contact

Deutsche Forschungsgemeinschaft
Kennedyallee 40
53175 Bonn

Is the project externally evaluated?


Who has evaluated, or will evaluate, the programme?


What forms of international collaboration does the programme support?

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Interdisciplinary research is a strategic priority...

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