Browse Ageing Research Programmes
German Research Foundation (Deutsche Forschungsgesellschaft)
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Total number of funded projects
Summary of key aims
Alzheimer's disease (AD) is characterized by the invariable accumulation of senile plaques, neurofbrillary tangles, and inflammatory processes. These pathological events are involved in the fatal neuronal cell observed in the brains of the patients. At lease five gene products (B-amyloid precursor protien, tau, Presenilin-1, Presenilin-2 and apoE) play a pivotal role in the pathogenesis of AD. It appears that miss-sorting and/or miss-function of these proteins is directly involved in amyloid plaque formation as weel as the accumulation of neurofibrillary tangles. Therefore a detailed understanding of the cell biology of these proteins and their cellular function will pave the way to understanding the patthological mechanisms causing AD. This may also help to identify novel targets for theraputic treatment. This program is therefore aimed to combine the efforts in cell biology and AD research and to provide a network within these two disciplines.
Is the project externally evaluated?
Who has evaluated, or will evaluate, the programme?
What forms of international collaboration does the programme support?
- ▪ Foreign collaborators working in their own countries
- ▪ Travel for foreign collaborators
- ▪ National researchers abroad
- ▪ Travel for national researchers
Interdisciplinary research is a strategic priority...
- For the programme ✔
- For the funding agency ✔
- Nationally ✔