Browse Ageing Research Programmes

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Funder/CentreGerman Research Foundation (Deutsche Forschungsgesel...
Programme:Molecular Pathology of Alzheimer Disease (Clinical R...
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German Research Foundation (Deutsche Forschungsgesellschaft)

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Molecular Pathology of Alzheimer Disease (Clinical Research Group; FOR 267)Research Programme

Website

http://www.gesundheitsforshcung-bmbf.de

Programme type

Research programme

Programme status

Closed

Total number of funded projects

6

Summary of key aims

Alzheimer disease (AD) is the cause of 60-75% of dementia cases in the elderly. Our knowledge abou the molecular processes involved in the etiopathogeneses of AD is limited. Neither a specifin nor otherwise highly efficient treatment of AD is currently available. The scientific work performed by the AD research unit Hamburg (ADRGH) aims at a better understanding of the etiology of AD, and the development of strategies both for its prevention and therapy in the future. The ADRGH consist of five groups working in clinical and basic science and collaborating very closely with each other. The projects are: (1) analysis of DNA polymorphisms in candidate genes for non-familial, sporadic AD, (2) development of a central repository for tissue, cerebrospinal fluid, and DNA samples, (3) development of a database for clinical assessment, (4) search for biological markers suitable for specific diagnosis and monitoring the clinical course of the disease, (5) molecular genetics of AD, (6) biochemical and cell biological investigations on tau protein in AD and in vitro, (7) role of apolipoprotein E, lipids, and lipid peroxidation in AD pathogenesis. One of the primary goals of the research work performed is the analysis of correlation between clinical phenotype and biological markers determined by the respective groups. Molecular genetic, cell biological, and biochemical studies are carried out on DNA and tissue samples caollected by the central repository and on experimental models of processes involved in neurodegeneration (e.g. protein aggregation or oxidation) in cell cultures and transgenic animals. The scientific work may result in an improved specificity of our present diagnostic tools or provide us with new tools suitable for specific diagnoses or for monitoring of establishing and novel therapies. Novel therapeutic approaches will also be assessed in Hamburg. The continuation of the series of scientific symposia in Hamburg (organised since 1999), and the great number of research papers published will promote national and international scientific communication. our local activities, i.e. the memory clinics and the genetic counselling unit, make an important contribution to patient and family care and should significantly improve public awareness of AD.

Management contact

Annette Schmidtmann
Annette.Schmidtmann@dfg.de
+49-(0)228-885-2243
Kennedyallee 40
53175 Bonn
Germany

Scientific contact

Ulrike Beisiegel
beisiegel@uke.uni-hamburg.de
+49-40-42803-3917
Universitat Hamburg
Martinistrasse 52
20246 Hamburg
Germany

Funding contact

Deutsche Forschungsgemeinschaft
postmaster@dfg.de
0228/885-1
Kennedyallee 40
53175 Bonn
Germany

Is the project externally evaluated?

Yes

Who has evaluated, or will evaluate, the programme?

Reviewers

What forms of international collaboration does the programme support?

  • ▪ Foreign collaborators working in their own countries
  • ▪ Travel for foreign collaborators
  • ▪ National researchers abroad
  • ▪ Travel for national researchers

Interdisciplinary research is a strategic priority...

  • For the programme ✔
  • For the funding agency ✔
  • Nationally ✔