Browse Ageing Research Programmes

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Funder/CentreMinistry of Health - Romania
Programme:Biomarkers of Ageing
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Ministry of Health - Romania

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Biomarkers of AgeingResearch Programme

Website

http://www.cnsis.ro

Programme type

Research programme

Programme status

Ongoing

Total number of funded projects

6

Summary of key aims

Aging per se is a risk factor for a variety of diseases. Chronological age cannot be used as a biomarker. In the absence of a more complete understanding of the mechanisms of aging, clinicians would like to have age related biomarkers. These biomarkers might be more than disease risk factors, and represent individual indicators of functional status. We will determine functional parameters, including anthropometric data, functional challenge tests, physiological tests, oxidative stress assessment, genomic and proteomic tests. Such a set of functional biomarkers of aging could be measured in a large group of subjects who are at an age where functional loss is known to occur most rapidly such as in the 45 to 55 and 55 to 65 age groups. Statistical evaluation of the data would help to identify tests that had the greatest predictive value when matched against functional outcome and morbidity patterns. Those with the highest predictive value would be defined as functional biomarkers of aging. What is learned from the study will be used to test therapies that could improve physiological, neuropsychological, cognitive and physical status and could slow accelerated ageing. These biomarkers of aging could be used to develop personalized medicine or other interventions which effectively reduce morbidity and improve organ-specific function by delaying the necessity for costly hospitalization or social support of the aging populations.

Management contact

Dr. Maria Georgescu
anaaslandirector@yahoo.com
(00)40 021 2224220
General Director, "Ana Aslan"
National Institute of Gerontology and Geriatrics
9 Caladarusani Str.
Sector 1
Bucharest
Romania
cod 011241

Admin contact

Ana Aslan National Institute of Gerontology and Ge
anaaslandirector@yahoo.com
(00)40 021 2224220
National Institute of Gerontology and Geriatrics
9 Caladarusani Str.
Sector 1
Bucharest
Romania
cod 011241

Scientific contact

Dr. Cornelia Rusu
anaaslandirector@yahoo.com
(00)40 021 2224220
Scientific Director "Ana Aslan"
National Institute of Gerontology and Geriatrics
9 Caladarusani Str.
Sector 1
Bucharest
Romania
cod 011241

Funding contact

Ministry of Health
m.coculescu@uni-davila.ro
++40 722 244 220
MC -University of Medicine & Pharmacy
"Carol Davila", Bucharest
37 Dionisie Lupu Street
Bucharest 020021
Romania
CP - PO Box 38-21
Bucharest 023573
Romania

Is the project externally evaluated?

No

Who has evaluated, or will evaluate, the programme?

Internal and external evaluators

Interdisciplinary research is a strategic priority...

  • For the programme ✔
  • For the funding agency ✔
  • Nationally ✔