Dietmar Herndler-Brandstetter

Austrian Academy of Sciences, Institute for Biomedical Ageing Research

Innsbruck, Austria

Photo of Dietmar Herndler-Brandstetter


Effect of interleukin 6 on T cell subsets in old age: A search for new markers of immunological competence and frailty


With respect to the current demographic development in many countries, infectious diseases in elderly persons are becoming an increasingly important issue. A key player involved in the regulation of inflammatory and immunologic responses is the cytokine interleukin (IL)-6, which increases with age and may contribute to a chronic inflammatory state in elderly persons ("inflamm-aging"). We therefore want to identify molecules related to IL-6 signaling in T cells which can be used as new diagnostic markers for immunological competence in old age and to predict a quick recovery or complications in patients under stress situation (e.g. hip fracture). The planned venture represents a good example of transdisciplinary research, as it combines biogerontological research and clinical application.


For the latest project poster please see the Documents below

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