Julia Kiyan

Hannover Medical School, Dept of Nephrology

Hannover, Germany

Project

The urokinase receptor in vascular ageing: regulatory mechanisms and clinical perspectives.

Summary

Even in the absence of recognized risk factors, ageing induces arterial wall thickening due to the alteration in the control mechanisms of vascular smooth muscle cells (VSMC) phenotypic modulations and functional behavior. This, in turn, leads to increased age-associated susceptibility to vascular diseases such as arteriosclerosis and restenosis. The research addresses molecular mechanisms of ageing-related vascular diseases. Our recent findings revealed potential activity of the urokinase receptor (uPAR) in regulation of VSMC phenotype and functions. The aim is to (i) elucidate uPAR function in ageing-related VSMC phenotypic changes and functional consequences, which are of clinical relevance and (ii) to develop in vitro model of VSMC phenotypic regulation by substrate topography applying methods of laser material processing as a new interdisciplinary approach to control vascular ageing.

Current research aims to identify target VSMC proteins and genes regulated by uPAR using in vitro model reflecting vascular ageing. Further evaluation of the obtained results in vivo will provide new cues for developing new theurapeutic approaches.

Posters

For the latest project poster please see the Documents below

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